formyl peptides

formyl peptides
Informal term for small peptides with a formylated N-terminal methionine and usually a hydrophobic amino acid at the carboxy-terminal end (fMetLeuPhe is the most commonly used). These peptides stimulate the motor and secretory activities of leucocytes, particularly neutrophils and monocytes, that have a specific receptor (about 60 kD) of high affinity (Kd approximately 10-8 M). Leucocytes show chemotaxis towards formyl peptides but the term chemotactic peptides understates the range of activities the molecules will trigger. Thought to be synthetic analogues of bacterial signal sequences - though this is unproven. The leucocytes of many animals (eg. pig, cow, chicken) do not respond.

Dictionary of molecular biology. 2004.

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  • Formyl peptide receptor 1 — Formyl peptide receptor 1, also known as FPR1, is a human gene.cite web | title = Entrez Gene: FPR1 formyl peptide receptor 1| url = Cmd=ShowDetailView TermToSearch=2357| accessdate = ] PBB Summary …   Wikipedia

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  • DMSO — Dimethyl sulphoxide. Much used as a solvent for substances that do not dissolve easily in water and that are to be applied to cells (for example cytochalasin B, formyl peptides), also as a cryoprotectant when freezing cells for storage. It is… …   Dictionary of molecular biology

  • fMLP — See formyl peptides …   Dictionary of molecular biology

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